The Hangover Hero is composed of highly purified extracts sourced from a number of natural occurring ingredients around the world. All statements below are referenced to the original research source and can be viewed by clicking on the information icon beside it. A proportion of the research used are in languages other than English, with translations provided.
Alcohol Metabolism Overview
As a basic overview, 90% of alcohol breakdown (metabolism) occurs in the liver and does so by using the enzymes alcohol dehydrogenase (ADH) followed by aldehyde dehydrogenase (ALDH). ALDH is responsible for reducing the toxic intermediate metabolite, acetaldehyde.
Toxins and damage to your liver often result in the increase of specific enzymes into your blood. These most notably include alanine trasaminase (ALT), aspartate transaminase (AST) and gamma glutamyl transpeptidase (GGT). The increase in these may be a good marker for liver injury or inflammation.
Veisalgia - the medical term for the hangover
Although the pathophysiology (underlying internal process causing the symptoms) is unknown for veisalgia, a number of theories exist including dehydration, accumulation of toxic metabolites (acetaldehyde), congeners, changes in sugar levels and wide-spread inflammation.
The reality is, it is probably a number of these factors that are responsible for the majority of the symptoms. Despite this, evidence demonstrates no correlation between them to the overall severity of the hangover apart from one - inflammation
The inflammatory response that you develop after drinking excessive alcohol leads to a number of mediators that are released, often causing the symptoms responsible for a hangover. A commonly tested inflammatory marker used by doctors is C-reactive protein and is largely elevated after a large consumption of alcohol.
The Hangover Hero has a number of herbal extracts that combine to combat the best proven causes of a hangover highlighted above without any synthetic pharmaceutical products. Here are a few of the key ingredients in detail:
Hangovers are largely due to the inflammatory response by your body after alcohol. A study looking at an extract from prickly pear demonstrated a reduction in the well known inflammation marker, C-reactive protein (CRP) when compared with placebo
Otherwise known as the oriental raisin tree, this tree is only found in parts of Asia. It has long been used by Chinese, Korean and Japanese medical practitioners for the treatment of fever, liver disease and alcohol detoxification. Herbal teas and juices made from this tree have long been associated with hepatoprotective and antioxidative properties
In mice, Hovenia dulcis fruits have been shown to reduce sleep time after alcohol consumption and also blood alcohol concentration compared with mice who did not have Hovenia dulcis fruits. It does not have a proven effect of bloody alcohol concentration in humans
Hovenia dulcis has also been shown to reduce damage to the liver after significant alcohol consumption in mice. In the study, mice who took hovenia dulcis juice with alcohol had decreased levels of enzymes commonly associated with liver damage (ALT, AST and GGT)
Furthermore, in mice, Hovenia ductis was shown to increase the breakdown of alcohol through the effects of the enzymes your body uses to break it down (ADH + ALDH). The study confirmed those mice that had Hovenia dulcis has increase activity of ADH and ALDH
Despite having an effect on both ADH and ALDH, the ALDH activity is increased more than ADH. ALDH is specifically responsible for breaking down the toxic metabolite, acetaldehyde form after the break down alcohol. Acetaldehyde has been shown to be up to 30 times more toxic than alcohol to your body and an increase in ALDH activity decreases its levels in your body
A herb well known for its liver protective factors, its active ingredients are collectively known as Silymarins.
Traditional Chinese medical practitioners have long used this herb for its hepatoprotective properties, particularly protecting the liver cells against toxins. An example trial demonstrated the decrease in ALT compared with control group when silybin (milk thistle extract) was used
Well known in the medical field for its liver protective factors after heavy paracetamol ingestion, N-Actyl L-Cysteine (NAC) is also a power antioxidant.
Studies have demonstrated that NAC offers promosing therapeutic value to inhibiting alcohol induced adverse effects, partly due to reducing oxidative stress in the body caused by excessive alcohol consumption
Vitamin C + B-group Vitamins
B-group vitamins that are depleted with alcohol consumption and are important for energy in the body. The ratio of B-group vitamins in The Hangover Hero are comparable to the Pabrinex® formulation doctors give alcoholics when they present to hospital. Vitamin C is a well known antioxidant with protective properties. Many well known formulations today market these vitamin products as a "hangover drink" or a "hangover treatment". Unfortunately, they are unlikely to help in isolation to reduce hangovers.